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KMID : 0811720140180010055
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 1 p.55 ~ p.59
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DehydroevodiamineㆍHCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats
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Kim Hee-Jin
Shin Ki-Young
Chang Keun-A
Ahn Sang-Zin
Choi Hee-Soon
Kim Hye-Sun
Suh Yoo-Hun
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Abstract
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DehydroevodiamineㆍHCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impair-ment and depression induced by stress.
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KEYWORD
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Depression, DHED, Fluoxetine, Memory, Stress
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